Kidney health can be affected by various conditions, one of which is IgA nephropathy. This disease results from the buildup of immunoglobulin A (IgA) protein in the kidney's blood-filtering structures. This accumulation leads to inflammation, tissue damage, and impaired kidney function.

Also referred to as Berger's disease, IgA nephropathy progresses slowly over several years. Without proper treatment, it can lead to kidney failure.

Causes of IgA Nephropathy

The exact cause of IgA nephropathy is not entirely understood. However, it is believed to be linked to abnormalities in the immune system.

The IgA protein helps the body combat infections. In individuals with IgA nephropathy, structural changes in this protein make it harder for the body to break down. Consequently, these altered proteins accumulate in the kidneys, causing inflammation.

While the specific cause remains uncertain, several factors may contribute to the development of IgA nephropathy:

Genetic Factors

This condition is more common among individuals with a family history of IgA nephropathy. Variations in certain immune system-related genes may increase susceptibility to the disease.

Immune System Disorders

Abnormalities in the immune system can heighten the risk of IgA accumulation, increasing the likelihood of developing this condition.

Digestive or Respiratory Tract Infections

Digestive or respiratory infections often trigger symptoms in individuals with IgA nephropathy. These infections can exacerbate IgA accumulation in the kidneys, leading to inflammation and further damage.

Other Medical Conditions

Certain diseases, such as cirrhosis of the liver, celiac disease, or dermatitis herpetiformis, are associated with a higher risk of IgA nephropathy.

Symptoms of IgA Nephropathy

In the early stages, IgA nephropathy may not present noticeable symptoms, which often leads to delayed detection. In many cases, the condition is only discovered after significant kidney damage has occurred.

Here are some common symptoms of IgA nephropathy:

• The presence of blood gives urine a pink, red, or brown (tea-like) appearance.
• Protein leakage into the urine indicates suboptimal kidney function in filtering blood.
• Kidney inflammation and damage can result in elevated blood pressure, which, in turn, worsens kidney damage.
• Swelling in the legs, hands, and face occurs due to fluid buildup in the body.
• Symptoms such as fatigue, nausea, and loss of appetite often accompany diminished kidney performance.

IgA nephropathy is a serious kidney condition that requires attention. If you notice one or more of the symptoms listed above, consult a doctor immediately for evaluation and treatment. For additional support, you can utilize health consultation services available through the Ai Care application, which can be downloaded from the App Store or Play Store.

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