Estradiol is a medication commonly used to alleviate menopausal symptoms. Menopause is a natural phase of a woman's life that marks the end of her menstrual cycle. It typically occurs between the ages of 45 and 55 and is characterized by a decrease in estrogen and progesterone levels in the ovaries. Symptoms of menopause, such as hot flashes, night sweats, vaginal dryness, mood swings, hair thinning, and decreased bone density, can interfere with quality of life.
Find out about the advantages and disadvantages of taking estradiol.
How does Estradiol work?
Estradiol is a synthetic estrogen used to treat symptoms associated with menopause or other conditions that cause low estrogen levels. It mimics the primary estrogen found in the human body. When estradiol enters the body, it binds to estrogen receptors found in estrogen-responsive tissues, including the brain, bones, liver, heart, and reproductive tissues.
Estradiol also regulates gonadotropin, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) levels through a negative feedback mechanism. In postmenopausal women, LH and FSH levels rise due to lower estrogen levels. The use of estradiol helps to lower these hormone levels in the blood, alleviating menopausal symptoms.
Benefits of Estradiol medication
Estradiol is a prescription medication used to treat various conditions, including:
- Managing menopausal symptoms such as hot flashes, night sweats, vaginal dryness, pain, and atrophy
- Maintaining bone density to help prevent osteoporosis, which is common among menopausal women
- Addressing abnormal uterine bleeding and severe pain caused by hormonal imbalance
- Treating certain cases of breast cancer and prostate cancer in men
Side effects of taking Estradiol
Estradiol is a powerful drug that must be taken with a prescription and under a doctor's supervision because it can cause a variety of side effects. The following side effects may occur when using estradiol:
- Bleeding outside the regular menstrual cycle
- Irregular or excessively long periods
- Breast pain and enlargement
- Sexual arousal changes, either increased or decreased
- Abdominal pain
- Fluid retention resulting in swelling
- Melasma or brown patches on the forehead, cheeks, or temples, which may persist even after discontinuing estradiol use
- Migraine headaches
- Changes in the cornea
- Blood clots, especially when taken in high doses
- Increased risk of endometrial cancer
To avoid unwanted side effects, use estradiol under the supervision of a doctor. Regular check-ups and reporting any side effects to your doctor are essential. It is also recommended to maintain a healthy lifestyle, including quitting smoking, to reduce the risks associated with estradiol use.
If you need medical advice or consultation, you can either visit a doctor or make use of the consultation features that are available in the Ai Care application by downloading the Ai Care application from the App Store or Play Store.
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- Sean Edbert Lim, MBBS
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Cleveland Clinic (2021). Menopause. Available from: https://my.clevelandclinic.org/health/diseases/21841-menopause
Drugs.com (2023). Estradiol: 7 things you should know. Available from: https://www.drugs.com/tips/estradiol-patient-tips